BindingDB PrimarySearch

BDBM50121975 (6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol::CARDIOQUIN::CHEMBL1294::CIN-QUIN::DURAQUIN::QUINACT::QUINAGLUTE::QUINALAN::QUINATIME::QUINIDEX::QUINIDINE::QUINORA::US9402878, Quinidine

SMILES: COc1ccc2c(c1)c(ccn2)[C@@H]([C@H]3C[C@@H]4CC[N@]3C[C@@H]4C=C)O

InChI Key: InChIKey=LOUPRKONTZGTKE-UHFFFAOYSA-N

Data: 7 KI 97 IC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 108 hits for monomerid = 50121975
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
UDP-glucuronosyltransferase 1A1 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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UDP-glucuronosyltransferase 1A4 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.66E+5	n/a	n/a	n/a	n/a	n/a	n/a
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UDP-glucuronosyltransferase 1-6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 2B7 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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UDP-glucuronosyltransferase 2B10 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.44E+3	n/a	n/a	n/a	n/a	7.0	n/a
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 3 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
ATP-binding cassette sub-family C member 2 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
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Reverse transcriptase (Human immunodeficiency virus type 1)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>6.16E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-dependent translocase ABCB1 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 1 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Cytochrome P450 2D6 (Human)	BDBM50121975 ((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
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