BDBM50127227 (R)-2,4,6-Trimethyl-deca-2,4-dienoic acid {(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-6-(2-hydroxy-5-oxo-cyclopent-1-enylcarbamoyl)-hexa-1,3,5-trienyl]-2-oxo-7-oxa-bicyclo[4.1.0]hept-3-en-3-yl}-amide::CHEMBL285848::manumycin A
SMILES CCCC[C@@H](C)C=C(C)C=C(C)C(=O)NC1=C[C@@](O)(\C=C\C=CC=CC(=O)NC2C(=O)CCC2=O)[C@@H]2O[C@@H]2C1=O
InChI Key InChIKey=XIZGHTZLVCHYJN-TZYHMVGPSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50127227
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Kumamoto University
Curated by ChEMBL
Kumamoto University
Curated by ChEMBL
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of [3H]-farnesyl pyrophosphate binding to human farnesyltransferaseMore data for this Ligand-Target Pair
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
Florida International University
Curated by ChEMBL
Florida International University
Curated by ChEMBL
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of NADPH-reduced recombinant rat TrxR1 expressed in Escherichia coli harboring gor mutant assessed as suppression of DTNB reduction incuba...More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences University
Curated by ChEMBL
Massachusetts College Of Pharmacy And Health Sciences University
Curated by ChEMBL
Affinity DataIC50: 3.58E+3nMAssay Description:Antiproliferative activity against human COLO 320DM cells harboring wild type KRAS assessed as reduction in cell viability incubated for 24 hrs in pr...More data for this Ligand-Target Pair
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
Florida International University
Curated by ChEMBL
Florida International University
Curated by ChEMBL
Affinity DataIC50: 272nMAssay Description:Inhibition of NADPH-reduced recombinant rat TrxR1 expressed in Escherichia coli harboring gor mutant assessed as suppression of DTNB reduction pretre...More data for this Ligand-Target Pair
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
Florida International University
Curated by ChEMBL
Florida International University
Curated by ChEMBL
Affinity DataIC50: 572nMAssay Description:Inhibition of NADPH-reduced recombinant rat TrxR1 expressed in Escherichia coli harboring gor mutant assessed as suppression of insulin reduction usi...More data for this Ligand-Target Pair