BDBM50131434 CHEMBL652::FLECAINIDE::N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide::N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide::N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide (Flecainide)::N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide(Flecainide)::N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide(Flecanide)::Tambocor

SMILES FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1

InChI Key InChIKey=DJBNUMBKLMJRSA-UHFFFAOYSA-N

Data  11 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50131434   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  3.89E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2J2(Homo sapiens (Human))
Tongji University

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  3.89E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 2(Rattus norvegicus)
Cardiome Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  1.01E+4nMAssay Description:Inhibition of rat potassium channel Kv4.2 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Cardiome Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of human heart sodium channel Nav1.5 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  2.71E+4nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  3.89E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  3.89E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 1(Homo sapiens (Human))
Dublin Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  2.09E+5nMAssay Description:Inhibition of Kv1.1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  2.18E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Cardiome Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50131434(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of human potassium channel Kv1.5 by patch-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed