BDBM50134495 1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoquinolinylcarboxamido]-(2R)-propanoyl]-1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]::1'-[3-(4-chlorophenyl)-2-[(3R)-1,4-dihydro-3-isoquinolinylcarboxamido]-(2R)-propanoyl]-1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]::CHEMBL338768

SMILES CS(=O)(=O)N1CC2(CCN(CC2)C(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H]2Cc3ccccc3CN2)c2ccccc12

InChI Key InChIKey=AYRYPORYMTYECQ-VSGBNLITSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50134495   

TargetMelanocyte-stimulating hormone receptor(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataIC50:  153nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataIC50:  66nMAssay Description:Inhibitory activity against [125I]-NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataEC50:  5.20nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataEC50:  190nMAssay Description:Agonistic activity measured as inhibition of cAMP accumulation in HEK cells expressing human Melanocortin 4 receptor (hMC4R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibitory activity against human melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed