BDBM501443 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- (pyrimidin-2-ylmethyl)pyrazolo[4,3-b]pyridin-7- amine::US11026923, Example 74

SMILES CCOc1ncccc1-c1cc(NCc2ncccn2)c(NC(C)C)c(n1)C(C)=N

InChI Key InChIKey=ZFZUGJNEEZJCBU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 501443   

LigandPNGBDBM501443(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- (py...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM501443(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- (py...)
Affinity DataIC50:  8.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM501443(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N- (py...)
Affinity DataIC50:  0.340nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent