BDBM50151864 CHEMBL184412::DRONEDARONE::N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide::N-(2-butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide::N-[2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide::SR 33589::SR 33589B

SMILES CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c1c(CCCC)oc2ccc(NS(C)(=O)=O)cc12

InChI Key InChIKey=ZQTNQVWKHCQYLQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50151864   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50:  316nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50:  2.37E+3nMAssay Description:Inhibition of human Kv1.5 channel expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tcg Lifesciences

Curated by ChEMBL
LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50:  6.84E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated with compound for 1 hr fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50:  3.92E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2  104 cells per well in DMEM, supplemented with 2% FBS and 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50151864(CHEMBL184412 | DRONEDARONE | N-(2-butyl-3-(4-(3-(d...)
Affinity DataIC50:  7.39E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed