BDBM50154944 CHEMBL3775535

SMILES CNC(=O)c1ccc2[nH]nc(Cc3ccc(cc3)-c3cnn(C)c3)c2c1

InChI Key InChIKey=OHNXBYACIOVGBQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50154944   

TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154944(CHEMBL3775535)
Affinity DataIC50:  15nMAssay Description:Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50154944(CHEMBL3775535)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50154944(CHEMBL3775535)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50154944(CHEMBL3775535)
Affinity DataIC50:  55nMAssay Description:Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed