BDBM50154948 CHEMBL3775895

SMILES Cn1cc(-c2ccc(Cc3n[nH]c4ccc(-c5cc(N)ccn5)cc34)cc2)cn1

InChI Key InChIKey=UQRFZZAOVZWDSA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50154948   

TargetCyclin-C(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50154948BDBM50154948(CHEMBL3775895)
Affinity DataIC50: 270nMAssay Description:Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Merck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50154948BDBM50154948(CHEMBL3775895)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed