BDBM50157821 (2R,6S,8S,10R)-4-[3-(trifluoromethyl)phenyl]-4-azatetracyclo[5.3.2.0^{2,6}.0^{8,10}]dodec-11-ene-3,5-dione::CHEMBL182993

SMILES Oc1c2C3C=CC([C@@H]4C[C@H]34)c2c(O)n1-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=SDYADZMWEXRUPW-BPNZPQAUSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50157821   

TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157821((2R,6S,8S,10R)-4-[3-(trifluoromethyl)phenyl]-4-aza...)
Affinity DataKi:  9nMAssay Description:Binding affinity for mutant T877A Androgen receptor in human LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157821((2R,6S,8S,10R)-4-[3-(trifluoromethyl)phenyl]-4-aza...)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity for androgen receptor in human MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157821((2R,6S,8S,10R)-4-[3-(trifluoromethyl)phenyl]-4-aza...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of androgen receptor in human MDA-453 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157821((2R,6S,8S,10R)-4-[3-(trifluoromethyl)phenyl]-4-aza...)
Affinity DataIC50:  148nMAssay Description:Inhibition of androgen dependent human prostate cancer cell MDA-MB-PCa2b proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50157821((2R,6S,8S,10R)-4-[3-(trifluoromethyl)phenyl]-4-aza...)
Affinity DataIC50:  30nMAssay Description:Inhibition of mutant T877A Androgen receptor in human LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed