BDBM50171520 (E)-4-Dimethylamino-but-2-enoic acid [4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-amide::CHEMBL190094

SMILES CN(C)C\C=C\C(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1

InChI Key InChIKey=XDYCDXFDVOBDOO-ONEGZZNKSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50171520   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171520((E)-4-Dimethylamino-but-2-enoic acid [4-(4,5-dichl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 4-10 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171520((E)-4-Dimethylamino-but-2-enoic acid [4-(4,5-dichl...)
Affinity DataIC50:  50nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 10-50 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171520((E)-4-Dimethylamino-but-2-enoic acid [4-(4,5-dichl...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171520((E)-4-Dimethylamino-but-2-enoic acid [4-(4,5-dichl...)
Affinity DataIC50:  50nMAssay Description:Inhibition of HER2 kinase in intact CSH12 cells; Range = 25-50 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171520((E)-4-Dimethylamino-but-2-enoic acid [4-(4,5-dichl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human PDGFR kinase in intact NIHPDGFR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University

Curated by ChEMBL
LigandPNGBDBM50171520((E)-4-Dimethylamino-but-2-enoic acid [4-(4,5-dichl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HER1 kinase in intact DHER14 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed