BDBM50171520 (E)-4-Dimethylamino-but-2-enoic acid [4-(4,5-dichloro-2-fluoro-phenylamino)-quinazolin-6-yl]-amide::CHEMBL190094
SMILES CN(C)C\C=C\C(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1
InChI Key InChIKey=XDYCDXFDVOBDOO-ONEGZZNKSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50171520
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 4-10 nMMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 10-50 nMMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Inhibition of EGF Receptor autophosphorylation in A431 cell lysateMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of HER2 kinase in intact CSH12 cells; Range = 25-50 nMMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human PDGFR kinase in intact NIHPDGFR cellsMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hadassah Hebrew University
Curated by ChEMBL
Hadassah Hebrew University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of HER1 kinase in intact DHER14 cellsMore data for this Ligand-Target Pair