BDBM50172062 CHEMBL3806108

SMILES CN(C)c1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccc2OCCOc2c1

InChI Key InChIKey=XYBLZFUVTDZOBZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50172062   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50172062(CHEMBL3806108)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of recombinant His6-tagged EGFR (unknown origin) cytoplasmic domain (645 to 1186 residues) autophosphorylation expressed in baculovirus in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Mus musculus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50172062(CHEMBL3806108)
Affinity DataIC50:  870nMAssay Description:Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr befor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Mus musculus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50172062(CHEMBL3806108)
Affinity DataIC50:  5.48E+3nMAssay Description:Inhibition of mouse c-Raf assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr before MEK1 ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed