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BDBM50173019 4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benzamide::4-[4-(4-tert-Butyl-phenylamino)-phthalazin-1-yl]-benzamide::CHEMBL370586::IM-094261

SMILES: CC(C)(C)c1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1

InChI Key: InChIKey=FIQNADOCRLODMD-UHFFFAOYSA-N

Data: 2 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50173019   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50173019
PNG
(4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benz...)
Show SMILES CC(C)(C)c1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1
Show InChI InChI=1S/C25H24N4O/c1-25(2,3)18-12-14-19(15-13-18)27-24-21-7-5-4-6-20(21)22(28-29-24)16-8-10-17(11-9-16)23(26)30/h4-15H,1-3H3,(H2,26,30)(H,27,29)
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MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 78n/an/an/an/an/an/a



ImClone Systems Inc

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method


Bioorg Med Chem 17: 731-40 (2009)


Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50173019
PNG
(4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benz...)
Show SMILES CC(C)(C)c1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1
Show InChI InChI=1S/C25H24N4O/c1-25(2,3)18-12-14-19(15-13-18)27-24-21-7-5-4-6-20(21)22(28-29-24)16-8-10-17(11-9-16)23(26)30/h4-15H,1-3H3,(H2,26,30)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 78n/an/an/an/an/an/a



ImClone Systems

Curated by ChEMBL


Assay Description
Inhibition of Vascular endothelial growth factor receptor 2 kinase phosphorylation of pGAT-biotin peptide


Bioorg Med Chem Lett 15: 4696-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.07.064
BindingDB Entry DOI: 10.7270/Q25Q4VNS
More data for this
Ligand-Target Pair