BDBM50174020 (S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-phenyl]-2-[5-(2-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoro)ethyl)-thiazolyl]ethyl}pyridine N-Oxide::2-{5-[(S)-1-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-ethyl]-thiazol-2-yl}-1,1,1,3,3,3-hexafluoro-propan-2-ol::CHEMBL199015::L-869298

SMILES OC(c1ncc(s1)[C@@H](Cc1ccc[n+]([O-])c1)c1ccc(OC(F)F)c(OC2CC2)c1)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=YDLQPURWTSDWCC-HNNXBMFYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50174020   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataKi:  6.14E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed