BDBM50180260 (Z)-2-(4-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one::2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one::CHEMBL426110

SMILES Oc1ccc(\C=C2/Oc3cc(O)ccc3C2=O)cc1

InChI Key InChIKey=KEZLDSPIRVZOKZ-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50180260   

TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataKi:  100nMAssay Description:Competitive inhibition of human recombinant MAOA using 0.006 to 0.15 mM kynuramine as substrate preincubated for 30 mins followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataKi:  510nMAssay Description:Competitive inhibition of human recombinant MAOB using 0.06 to 1.5 mM benzylamine as substrate preincubated for 30 mins followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataIC50: 5.28E+3nMAssay Description:Inhibition of human recombinant MAO-A using p-tyramine as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus-infected BTI cells using benzylamine as substrate preincubated with enzyme for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosinase(Human)
Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataIC50: 3.84E+4nMAssay Description:Inhibitory activity against tyrosinase in human melanocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataIC50: 3.84E+4nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50180260(2-(4'-Hydroxybenzylidene)-6-hydroxybenzofuran-3(2H...)
Affinity DataIC50: 3.84E+4nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed