BDBM50183788 3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)-N-(pyridin-4-yl)benzamide::CHEMBL383837

SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccncc2)c2ncccc2c1)S(C)(=O)=O

InChI Key InChIKey=XVFXPIPTQRSUTA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183788   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183788(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human GST-PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183788(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183788(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)
Affinity DataIC50:  200nMAssay Description:Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183788(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183788(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human GST-PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed