BDBM50183804 4-(2-hydroxypropan-2-yl)-N-(4-(methylsulfonyl)phenyl)-N-(1-(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)phenyl)ethyl)benzamide::CHEMBL380933

SMILES CC(N(C(=O)c1ccc(cc1)C(C)(C)O)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O

InChI Key InChIKey=DAHVRHNHMXYVKR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183804   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183804(4-(2-hydroxypropan-2-yl)-N-(4-(methylsulfonyl)phen...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human GST-PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183804(4-(2-hydroxypropan-2-yl)-N-(4-(methylsulfonyl)phen...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human GST-PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183804(4-(2-hydroxypropan-2-yl)-N-(4-(methylsulfonyl)phen...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183804(4-(2-hydroxypropan-2-yl)-N-(4-(methylsulfonyl)phen...)
Affinity DataIC50:  270nMAssay Description:Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183804(4-(2-hydroxypropan-2-yl)-N-(4-(methylsulfonyl)phen...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed