BDBM50183808 CHEMBL383225::N-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)methyl)-N-(4-(methylsulfonyl)phenyl)benzamide

SMILES CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)c3ccccc3)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1

InChI Key InChIKey=UZMVNVNNMNSBTP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50183808   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183808(CHEMBL383225 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human GST-PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183808(CHEMBL383225 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  80nMAssay Description:Ability to block TNFalpha release through inhibition of PDE4 in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183808(CHEMBL383225 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183808(CHEMBL383225 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human GST-PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50183808(CHEMBL383225 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human GST-PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed