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BDBM50185084 2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide::2-(3,4-dimethoxybenzamido)-5-methyl-4-propylthiophene-3-carboxamide::CHEMBL210833

SMILES: COc1ccc(cc1OC)C(=O)Nc1sc2CCCCc2c1C(N)=O

InChI Key: InChIKey=FSPQCTGGIANIJZ-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50185084   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50185084
PNG
(2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo...)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1sc2CCCCc2c1C(N)=O
Show InChI InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

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DrugBank
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CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Duquesne University

Curated by ChEMBL


Assay Description
Inhibition of Flt3 activity in human MV 3:11 cells by phosphotyrosine cell-based ELISA


J Med Chem 53: 1563-78 (2010)


Article DOI: 10.1021/jm9011142
BindingDB Entry DOI: 10.7270/Q2SX6F6D
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50185084
PNG
(2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo...)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1sc2CCCCc2c1C(N)=O
Show InChI InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of FLT3


Bioorg Med Chem Lett 16: 3282-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.032
BindingDB Entry DOI: 10.7270/Q2R49QCV
More data for this
Ligand-Target Pair