BDBM50200099 2-Amino-1,7-dihydro-purine-6-thione::2-Amino-1,9-dihydro-purine-6-thione::2-Amino-9H-purine-6-thiol::2-amino-1,9-dihydro-6H-purine-6-thione::2-amino-1H-purine-6(7H)-thione::2-amino-1H-purine-6(9H)-thione::6-thioguanine::CHEMBL727::THIOGUANINE::Thioquanine::Tioguanine

SMILES Nc1nc2nc[nH]c2c(=S)[nH]1

InChI Key InChIKey=WYWHKKSPHMUBEB-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50200099   

TargetPolyphenol oxidase 2(White button mushroom)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50200099(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)
Affinity DataKi:  5.20E+4nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase(Escherichia coli (strain K12))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50200099(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50200099(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of human USP2 (258 to 605 residues) catalytic domain by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50200099(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TAP-tagged SARS-CoV-2 papain-like protease nsp23More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50200099(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of SARS-CoV-2 papain-like protease-mediated de-ISGylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50200099(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of SARS-CoV-2 papain-like proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Human)
Institute of Biological Chemistry and The Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM50200099(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)
Affinity DataIC50:  9.24E+4nMAssay Description:Inhibition of human xanthine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50200099(2-Amino-1,7-dihydro-purine-6-thione | 2-Amino-1,9-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TAP-tagged SARS-CoV-2 papain-like protease nsp123More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed