BDBM50200392 CHEMBL383899::Cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide::N-3-4-3-trifluoromethyl)phenylamino)pyrimidin-2-ylamino)phenyl)cyclopropanecarboxamide::N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE

SMILES FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1

InChI Key InChIKey=RDTDWGQDFJPTPD-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50200392   

TargetAurora kinase A(Homo sapiens (Human))
Activesight

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50:  42nMAssay Description:Inhibition of Aurora-AMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Activesight

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Activesight

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50:  42nMAssay Description:Inhibition of Aurora kinase AChecked by AuthorMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Activesight

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50:  42nMAssay Description:Inhibition of Aurora A kinase (unknown origin)More data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50:  386nMAssay Description:Inhibition of BmxChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50:  591nMAssay Description:Inhibition of IGF1RChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50:  887nMAssay Description:Inhibition of SykChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50200392(CHEMBL383899 | Cyclopropanecarboxylic acid-(3-(4-(...)
Affinity DataIC50:  131nMAssay Description:Inhibition of LckChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed