BDBM50200394 CHEMBL387187::Cyclopropanecarboxylic acid (3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide::N-3-6-3-trifluoromethyl)phenylamino)pyrimidin-4-ylamino)phenyl)cyclopropanecarboxamide

SMILES FC(F)(F)c1cccc(Nc2cc(Nc3cccc(NC(=O)C4CC4)c3)ncn2)c1

InChI Key InChIKey=YOHYSYJDKVYCJI-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50200394   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Activesight

Curated by ChEMBL
LigandPNGBDBM50200394(CHEMBL387187 | Cyclopropanecarboxylic acid (3-(6-(...)
Affinity DataIC50:  21nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50200394(CHEMBL387187 | Cyclopropanecarboxylic acid (3-(6-(...)
Affinity DataIC50:  7.64E+3nMAssay Description:Inhibition of erbB4/Her4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Activesight

Curated by ChEMBL
LigandPNGBDBM50200394(CHEMBL387187 | Cyclopropanecarboxylic acid (3-(6-(...)
Affinity DataIC50:  21nMAssay Description:Inhibition of wild type EGFRChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Activesight

Curated by ChEMBL
LigandPNGBDBM50200394(CHEMBL387187 | Cyclopropanecarboxylic acid (3-(6-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Aurora-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed