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BDBM50203356 1-(7-amino-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazin-1-yl)propyl)urea::CHEMBL426339

SMILES: CN1CCN(CCCN(C2CCc3ccc(N)cc3C2)C(=O)Nc2ccc(F)c(Cl)c2)CC1

InChI Key: InChIKey=AMCXJTXNFNTRKC-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50203356   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50203356
PNG
(1-(7-amino-1,2,3,4-tetrahydronaphthalen-2-yl)-3-(3...)
Show SMILES CN1CCN(CCCN(C2CCc3ccc(N)cc3C2)C(=O)Nc2ccc(F)c(Cl)c2)CC1
Show InChI InChI=1S/C25H33ClFN5O/c1-30-11-13-31(14-12-30)9-2-10-32(25(33)29-21-6-8-24(27)23(26)17-21)22-7-4-18-3-5-20(28)15-19(18)16-22/h3,5-6,8,15,17,22H,2,4,7,9-14,16,28H2,1H3,(H,29,33)
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Similars

Article
PubMed
260n/an/an/an/an/an/an/an/a



Pharmacopeia Drug Discovery Inc

Curated by ChEMBL


Assay Description
Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranes


Bioorg Med Chem Lett 17: 1718-21 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.080
BindingDB Entry DOI: 10.7270/Q26H4H3Q
More data for this
Ligand-Target Pair