BDBM50204579 CHEMBL247866::N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)furo[2,3-d]pyrimidin-4-amine

SMILES CC(C)Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCC2)cc1

InChI Key InChIKey=SSVDSZIWJBBCNN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50204579   

TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 36nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 78nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 537nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 914nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of Jak3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 3.27E+3nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 4.89E+3nMAssay Description:Inhibition of Jak2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 8.33E+3nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed