BDBM50208138 (+)-acifran::(-)-acifran::5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid::5-methyl-4-oxo-5-phenyl-4,5-dihydrofuran-2-carboxylic acid::CHEMBL278488::acifran

SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1

InChI Key InChIKey=DFDGRKNOFOJBAJ-UHFFFAOYSA-N

Data  3 IC50  7 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50208138   

TargetHydroxycarboxylic acid receptor 3(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataEC50:  4.20E+3nMAssay Description:Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataEC50:  1.30E+3nMAssay Description:Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 3(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataEC50:  4.20E+3nMAssay Description:Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataIC50:  500nMAssay Description:Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataEC50:  1.30E+3nMAssay Description:Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataIC50:  500nMAssay Description:Activity at GPR109a (unknown origin) assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 3(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataEC50:  316nMAssay Description:Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHydroxycarboxylic acid receptor 3(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208138((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Affinity DataIC50:  3.00E+3nMAssay Description:Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)