BDBM50209971 1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-acetylphenyl)urea::CHEMBL250689
SMILES CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1
InChI Key InChIKey=ASRDPULQBHFPGU-WFIHMLKPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50209971
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 490nMAssay Description:Binding affinity to dopamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 950nMAssay Description:Binding affinity to norepinephrine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 2.90E+3nMAssay Description:Binding affinity to serotonin transporterMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.0340nMAssay Description:Inhibition of eotaxin-induced chemotaxis of human eosinophilsMore data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-X-C chemokine receptor type 2More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-X-C chemokine receptor type 1More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.0340nMAssay Description:Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsMore data for this Ligand-Target Pair
TargetProbable C-C chemokine receptor type 3(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsMore data for this Ligand-Target Pair
TargetProbable C-C chemokine receptor type 3(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of dopamine D2 receptorMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 920nMAssay Description:Inhibition of 5HT2A receptorMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.0340nMAssay Description:Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.0340nMAssay Description:Antagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assayMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Binding affinity to CCR3More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of C-C chemokine receptor type 5More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-C chemokine receptor type 2More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-C chemokine receptor type 1More data for this Ligand-Target Pair
TargetProbable C-C chemokine receptor type 3(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of calcium mobilization in human eosinophilsMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.0390nMAssay Description:Inhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophilsMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of [125I]-eotaxin binding to human eosinophilsMore data for this Ligand-Target Pair