BDBM50220302 1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-(2,2,2-trifluoroethyl)piperidin-2-yl)cyclopropyl 4-(piperidin-1-yl)piperidine-1-carboxylate::CHEMBL442801

SMILES FC(F)(F)C[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CCC(CC1)N1CCCCC1

InChI Key InChIKey=OSXBZLBBJZHPPI-LADGPHEKSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50220302   

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220302(1-((2R,6S)-1-(4-chlorophenylsulfonyl)-6-(2,2,2-tri...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed