BDBM50221550 4-(7-(2,6-difluoro-3-hydroxyphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide::CHEMBL440963::US8481536, 556

SMILES Cc1cc(cc2nnc(Nc3ccc(cc3)S(=O)(=O)NCCN3CCCC3)nc12)-c1c(F)ccc(O)c1F

InChI Key InChIKey=GPTPEUDRFUOZSX-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50221550   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50221550(4-(7-(2,6-difluoro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50221550(4-(7-(2,6-difluoro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair
In DepthDetails
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Targegen

Curated by ChEMBL
LigandPNGBDBM50221550(4-(7-(2,6-difluoro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataKi:  51nMMore data for this Ligand-Target Pair
In DepthDetails
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Targegen

US Patent
LigandPNGBDBM50221550(4-(7-(2,6-difluoro-3-hydroxyphenyl)-5-methylbenzo[...)
Affinity DataIC50:  3.10nMT: 2°CAssay Description:Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp.More data for this Ligand-Target Pair
In DepthDetails US Patent