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BDBM50229188 CHEMBL4096996

SMILES: CC(C)N(C(C)C)C(=O)N(C)Cc1cc(F)cc(F)c1F

InChI Key: InChIKey=RESQIMKKDLPZLK-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229188   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229188
PNG
(CHEMBL4096996)
Show SMILES CC(C)N(C(C)C)C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C15H21F3N2O/c1-9(2)20(10(3)4)15(21)19(5)8-11-6-12(16)7-13(17)14(11)18/h6-7,9-10H,8H2,1-5H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
More data for this
Ligand-Target Pair