BDBM50229660 3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((4-o-tolylpiperidin-1-ylsulfonyl)methyl)piperidine-1-carboxylate::CHEMBL254492

SMILES Cc1ccccc1C1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC1(C)CCOC1)C(=O)NO

InChI Key InChIKey=CTRWITLGGIGPOB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50229660   

LigandPNGBDBM50229660(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)
Affinity DataIC50:  36nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229660(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229660(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229660(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)
Affinity DataIC50:  264nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed