BDBM50231459 CHEMBL252818::N-(6-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-2,3-dihydro-1H-inden-1-yl)acetamide

SMILES CC(=O)NC1CCc2ccc(CCN3CCN(CC3)c3nsc4ccccc34)cc12

InChI Key InChIKey=ACZCVZUKGWGYJX-UHFFFAOYSA-N

Data  5 KI

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50231459   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50231459(CHEMBL252818 | N-(6-(2-(4-(benzo[d]isothiazol-3-yl...)
Show SMILES CC(=O)NC1CCc2ccc(CCN3CCN(CC3)c3nsc4ccccc34)cc12
Show InChI InChI=1S/C24H28N4OS/c1-17(29)25-22-9-8-19-7-6-18(16-21(19)22)10-11-27-12-14-28(15-13-27)24-20-4-2-3-5-23(20)30-26-24/h2-7,16,22H,8-15H2,1H3,(H,25,29)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in Swiss 3T3 cellsMore data for this Ligand-Target Pair
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50231459(CHEMBL252818 | N-(6-(2-(4-(benzo[d]isothiazol-3-yl...)
Show SMILES CC(=O)NC1CCc2ccc(CCN3CCN(CC3)c3nsc4ccccc34)cc12
Show InChI InChI=1S/C24H28N4OS/c1-17(29)25-22-9-8-19-7-6-18(16-21(19)22)10-11-27-12-14-28(15-13-27)24-20-4-2-3-5-23(20)30-26-24/h2-7,16,22H,8-15H2,1H3,(H,25,29)
Affinity DataKi:  1.34nMAssay Description:Displacement of [3H]prazosin from rat adrenergic alpha1A receptor expressed in fibroblast cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50231459(CHEMBL252818 | N-(6-(2-(4-(benzo[d]isothiazol-3-yl...)
Show SMILES CC(=O)NC1CCc2ccc(CCN3CCN(CC3)c3nsc4ccccc34)cc12
Show InChI InChI=1S/C24H28N4OS/c1-17(29)25-22-9-8-19-7-6-18(16-21(19)22)10-11-27-12-14-28(15-13-27)24-20-4-2-3-5-23(20)30-26-24/h2-7,16,22H,8-15H2,1H3,(H,25,29)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]8OHDPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50231459(CHEMBL252818 | N-(6-(2-(4-(benzo[d]isothiazol-3-yl...)
Show SMILES CC(=O)NC1CCc2ccc(CCN3CCN(CC3)c3nsc4ccccc34)cc12
Show InChI InChI=1S/C24H28N4OS/c1-17(29)25-22-9-8-19-7-6-18(16-21(19)22)10-11-27-12-14-28(15-13-27)24-20-4-2-3-5-23(20)30-26-24/h2-7,16,22H,8-15H2,1H3,(H,25,29)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]spiperone from human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50231459(CHEMBL252818 | N-(6-(2-(4-(benzo[d]isothiazol-3-yl...)
Show SMILES CC(=O)NC1CCc2ccc(CCN3CCN(CC3)c3nsc4ccccc34)cc12
Show InChI InChI=1S/C24H28N4OS/c1-17(29)25-22-9-8-19-7-6-18(16-21(19)22)10-11-27-12-14-28(15-13-27)24-20-4-2-3-5-23(20)30-26-24/h2-7,16,22H,8-15H2,1H3,(H,25,29)
Affinity DataKi:  885nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair