BDBM50233277 CHEMBL4085873

SMILES Cc1ccc(C(O)=O)c(CC[C@@H]2CCC[C@@H]2NC(=O)C2CCN(CC2)c2ccc(cc2)C(F)(F)F)c1

InChI Key InChIKey=KXWMXOZYHJJCBI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50233277   

TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233277(CHEMBL4085873)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233277(CHEMBL4085873)
Affinity DataIC50: 3nMAssay Description:Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed