BDBM50233808 CHEMBL4086701::US11021454, Compound 6e

SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)\C=C\c1ccc(O)c2oc(cc12)-c1ccc(O)c(O)c1

InChI Key InChIKey=QAUZVAOGKLECFY-GSXXRBPTSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50233808   

TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50233808(CHEMBL4086701 | US11021454, Compound 6e)
Affinity DataKi:  3.43E+3nMAssay Description:Mixed-type competitive inhibition of Xanthine oxidase (unknown origin) assessed as enzyme-inhibitor complex preincubated for 3 mins followed by xanth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50233808(CHEMBL4086701 | US11021454, Compound 6e)
Affinity DataIC50:  6.47E+3nMAssay Description:12.1 Preparation of Reagents and Standard Solutions(1) Preparation of DPPH solution: accurately weigh the appropriate amount of DPPH, add MeOH and pe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50233808(CHEMBL4086701 | US11021454, Compound 6e)
Affinity DataIC50:  4.51E+3nMAssay Description:11.1 Preparation of Reagents and Standard Solutions(1) 75 mM phosphate buffer (PB, pH 7.4): containing KH2PO4 0.0956 g, K2HPO4 0.6946 g, EDTA 1.862 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50233808(CHEMBL4086701 | US11021454, Compound 6e)
Affinity DataIC50:  4.51E+3nMAssay Description:Inhibition of Xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 3 mins followed by substrate addition measured every 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed