BDBM50238071 CHEMBL4079857
SMILES Cc1ccc(F)c(c1)-c1cc(Nc2ccnc3cnn(C)c23)c(C)cn1
InChI Key InChIKey=CKZSWAJXGWJYKE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50238071
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant N-terminal GST tagged human ALK5 (200 to 503 residues) expressed in baculovirus expression system using FAM-NH2-KVLTQMGSPSI...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Inhibition of ALK5 in human Calu6 cells assessed as reduction in Smad2/3 phosphorylationMore data for this Ligand-Target Pair
Affinity DataEC50: 6.30nMAssay Description:Inhibition of ALK5 (unknown origin) expressed in SBE-bla HEK293T cells assessed as decrease in TGFbeta1-induced Smad2/3 phosphorylation by beta lacta...More data for this Ligand-Target Pair