BDBM50240278 CHEMBL4062780
SMILES CC1(C)CN2CCC[C@]2(CNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)C1
InChI Key InChIKey=XBIMZDZZPNFVOV-LJQANCHMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50240278
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam/testosterone as substrate after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataEC50: 5.60E+3nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after hyperpolarization to -115 mV for 8s followed by 20ms p...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after depolarization to 7 mV for 8s followed by 20ms pulse w...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using warfarin as substrate after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair