BDBM50240433 5-Isopropyl-2-methyl-phenol::CARVACROL::CHEMBL281202

SMILES CC(C)c1ccc(C)c(O)c1

InChI Key InChIKey=RECUKUPTGUEGMW-UHFFFAOYSA-N

Data  6 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50240433   

TargetSecreted chorismate mutase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Birla Institute of Technology

LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataIC50:  1.06E+3nMpH: 7.5 T: 37°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataEC50:  7.00E+3nMAssay Description:Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Horse)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataIC50:  4.11E+5nMAssay Description:Inhibition of horse serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
School of Health Sciences/Graduate Program In Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataIC50:  2.84E+5nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(White button mushroom)
Susquehanna University

Curated by ChEMBL
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate measured after 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataEC50:  1.70E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataEC50:  1.66E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electric eel)
Bezmialem Vakif University

Curated by ChEMBL
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataIC50:  2.88E+5nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed