BDBM50242015 CHEMBL518543::Kuwanon C, 4::kuwanon C

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c2c1oc(-c1ccc(-[#8])cc1-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c2=O

InChI Key InChIKey=UWQYBLOHTQWSQD-UHFFFAOYSA-N

Data  3 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50242015   

TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataKi:  80.5nM ΔG°:  -9.83kcal/moleT: 2°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataKi:  2.20E+3nMAssay Description:Noncompetitive inhibition of human recombinant BACE-1 by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataIC50:  310nMAssay Description:Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))TBA
LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of BuChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetBeta-secretase 1(Homo sapiens (Human))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataIC50: >3.00E+5nMT: 2°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataIC50:  1.35E+5nMT: 2°CAssay Description:Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Sus scrofa (Pig))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50242015(CHEMBL518543 | Kuwanon C, 4 | kuwanon C)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate assessed as formation of p-nitrophenol preincubated for 15 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed