BDBM50243895 1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane::1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane::CHEMBL528995
SMILES Clc1ccc(cc1Cl)C12CC1CNC2
InChI Key InChIKey=BSMNRYCSBFHEMQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 50243895
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataKi: 63nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 251nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataIC50: 143nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 394nMAssay Description:Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant human CYP1A2 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 780nMAssay Description:Inhibition of recombinant human CYP2D6 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.90E+4nMAssay Description:Inhibition of recombinant human CYP2C9 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human CYP3A4 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant human CYP2C19 preincubated for 5 mins before fluorescent substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 723nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 88nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Neurocrine Biosciences
Curated by ChEMBL
Neurocrine Biosciences
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Neurocrine Biosciences
Curated by ChEMBL
Neurocrine Biosciences
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of dopamine uptake at cloned DAT in rat brain synaptosomeMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of norepinephrine uptake at human cloned NETMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of serotonin uptake at human cloned SERTMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of dopamine uptake at human cloned DATMore data for this Ligand-Target Pair
Affinity DataIC50: 215nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataIC50: 72.4nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in MDCK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 93.8nMAssay Description:Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Roche Palo Alto
Curated by ChEMBL
Roche Palo Alto
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of [3H]norepinephrine reuptake at human NET expressed in MDCK cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair