BDBM50252193 4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one::4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-[6-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-4-methyl-1H-benzoimidazol-2-yl]-1H-pyridin-2-one::CHEMBL482101
SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCC2(CC1)OCCO2
InChI Key InChIKey=OQEBLEZRSCIFJK-HSZRJFAPSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50252193
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 121nMAssay Description:Inhibition of IGF1R in mouse SAL cells assessed as thymidine incorporationMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP3A4 after 20 mins by BFC fluorescence assayMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair