BDBM50252395 CHEMBL4087616

SMILES CN1C(=O)C2CN(Cc3c2c2ccccc2n3Cc2ccc(cc2)C(=O)NO)C1=O

InChI Key InChIKey=ZCAIUGLOTHAUQX-UHFFFAOYSA-N

Data  10 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50252395   

TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  0.700nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus-infected Sf9 insect cells using RHKK(Ac)AMC as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  173nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC8 (1 to 377 residues) expressed in baculovirus-infected insect cells using RHK(Ac)K(Ac)AMC ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  306nMAssay Description:Displacement of [125I]-NDP-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  358nMAssay Description:Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus-infected Sf21 insect cells using RHKK(Ac)AMC as substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  442nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in baculovirus-infected insect cells after 60 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  452nMAssay Description:Inhibition of recombinant human HDAC10 expressed in baculovirus-infected insect cells using fluorogenic peptide RHKKAc as substrate by fluorimeterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  495nMAssay Description:Inhibition of recombinant human N-terminal His-tagged HDAC11 (1 to 347 residues) expressed in baculovirus-infected insect cells using RHKK(Ac)AMC as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  701nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC5 (656 to 1122 residues) expressed in baculovirus-infected insect cells using Boc-Lys(TFA)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  774nMAssay Description:Inhibition of full length recombinant human C-terminal GST-tagged HDAC2 expressed in baculovirus-infected insect cells using RHKK(Ac)AMC as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataKi:  1.82E+3nMAssay Description:Inhibition of recombinant human C-terminal GST-tagged HDAC4 expressed in baculovirus-infected insect cells using Boc-Lys(TFA)-AMC as substrate by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  1.57E+3nMAssay Description:Inhibition of human HDAC5 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  250nMAssay Description:Inhibition of human HDAC8 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  4nMAssay Description:Inhibition of human HDAC6 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  3.82E+3nMAssay Description:Inhibition of human HDAC4 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  7.45E+3nMAssay Description:Inhibition of human HDAC2 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  3.62E+3nMAssay Description:Inhibition of human HDAC1 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50252395(CHEMBL4087616)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human HDAC10 using RHKKAc as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed