BDBM50252777 CHEMBL523374::N,6-Dimethyl-7-(1-((S)-3-methylmorpholino)phthalazin-6-yl)-benzo[d]isoxazol-3-amine
SMILES CNc1noc2c(c(C)ccc12)-c1ccc2c(nncc2c1)N1CCOC[C@@H]1C
InChI Key InChIKey=RXQPWAXTLUQACC-AWEZNQCLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50252777
Affinity DataKi: 0.400nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Inhibition of human recombinant GST-tagged p38beta-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human ERG by manual electrophysiologyMore data for this Ligand-Target Pair
Affinity DataIC50: 830nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of c-KIT (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair