BDBM50253700 CHEMBL4065361

SMILES Cc1n[nH]cc1-c1cc2nc([nH]c(=O)c2s1)C(N1CCCC1)c1ccccc1

InChI Key InChIKey=JHSCGTOSSCUERL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50253700   

TargetRho-associated protein kinase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50253700(CHEMBL4065361)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROCK1 catalytic domain (1 to 477 residues) expressed in baculovirus expression system using Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2019
Entry Details Article
PubMed
LigandPNGBDBM50253700(CHEMBL4065361)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50253700(CHEMBL4065361)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of full length human CDC2 (1 to 298 residues)/human N-terminal GST-tagged CyclinE1 (1 to 410 residues) expressed in baculovirus expression...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2019
Entry Details Article
PubMed