BDBM50264942 (S)-4-(6-(1-hydroxy-3-methylbutan-2-ylamino)imidazo[1,2-b]pyridazin-3-yl)benzonitrile::4-(6-{[(1S)-1-(HYDROXYMETHYL)-2-METHYLPROPYL]AMINO}IMIDAZO[1,2-B]PYRIDAZIN-3-YL)BENZONITRILE::CHEMBL495709::US10688093, Compound 229_0254_0086::US11701353, Compound 229_0254_0086

SMILES CC(C)[C@@H](CO)Nc1ccc2ncc(-c3ccc(cc3)C#N)n2n1

InChI Key InChIKey=CQZVJEKKNHOFNB-OAHLLOKOSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50264942   

TargetProtein kinase domain-containing protein(Plasmodium falciparum)
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50264942((S)-4-(6-(1-hydroxy-3-methylbutan-2-ylamino)imidaz...)
Affinity DataIC50:  280nMAssay Description:Inhibition of Plasmodium falciparum PK7More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50264942((S)-4-(6-(1-hydroxy-3-methylbutan-2-ylamino)imidaz...)
Affinity DataIC50:  3.18E+3nMAssay Description:The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein kinase domain-containing protein(Plasmodium falciparum)
Mrc Technology

Curated by ChEMBL
LigandPNGBDBM50264942((S)-4-(6-(1-hydroxy-3-methylbutan-2-ylamino)imidaz...)
Affinity DataIC50:  280nMAssay Description:Inhibition of Plasmodium falciparum protein kinase 7More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50264942((S)-4-(6-(1-hydroxy-3-methylbutan-2-ylamino)imidaz...)
Affinity DataIC50:  3.18E+3nMAssay Description:The ADP-Glo™ Kinase Assay is specifically designed to quantify kinase activity by measuring the ADP produced in the reaction The reaction buffer...More data for this Ligand-Target Pair