BDBM50265973 CHEMBL4075638

SMILES C[C@H]1Cn2cc(cc2C(=O)N1Cc1cccc(C)n1)-c1nc(Nc2ccnn2C)ncc1C

InChI Key InChIKey=VKGZTIYOOVDXAF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50265973   

TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265973(CHEMBL4075638)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 60 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265973(CHEMBL4075638)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265973(CHEMBL4075638)
Affinity DataIC50: 140nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50265973(CHEMBL4075638)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50265973(CHEMBL4075638)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2020
Entry Details Article
PubMed