BDBM50277416 CHEMBL4161988

SMILES COc1ccc(cc1OC)-c1nc(Nc2cccc(c2)S(F)(=O)=O)c2ccccc2n1

InChI Key InChIKey=TVLUSQOSWMGZFO-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50277416   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50277416(CHEMBL4161988)Copy SMILESCopy InChI

Affinity DataIC50: 570nMAssay Description:Inhibition of human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins followed by Hoech...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/2/2020
Entry Details Article
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TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50277416(CHEMBL4161988)Copy SMILESCopy InChI

Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-AM addition meas...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/2/2020
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL