BDBM50285607 MLN-4924::MLN-4924003::Pevonedistat

SMILES: [H][C@]1(O)C[C@@]([H])(C[C@@]1([H])COS(N)(=O)=O)n1ccc2c(N[C@@]3([H])CCc4ccccc34)ncnc12

InChI Key: InChIKey=MPUQHZXIXSTTDU-UHFFFAOYSA-N

Data: 14 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50285607   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ubiquitin-like modifier-activating enzyme 1 (Mouse)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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NEDD8-activating enzyme E1 regulatory subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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NEDD8-activating enzyme E1 regulatory subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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NEDD8-activating enzyme E1 catalytic subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
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NEDD8-activating enzyme E1 catalytic subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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NEDD8-activating enzyme E1 catalytic subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
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Ubiquitin-like modifier-activating enzyme ATG7 (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Ubiquitin-like modifier-activating enzyme 6 (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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NEDD8-activating enzyme E1 regulatory subunit/NEDD8-activating enzyme E1 catalytic subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a
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SUMO-activating enzyme subunit 1/2 (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NEDD8-activating enzyme E1 catalytic subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NEDD8-activating enzyme E1 regulatory subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
NEDD8-activating enzyme E1 catalytic subunit (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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NEDD8 (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme 6 (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ubiquitin-like modifier-activating enzyme ATG7 (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
SUMO-activating enzyme subunit 1/2 (Human)	BDBM50285607 (MLN-4924 | MLN-4924003 | Pevonedistat) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair