BDBM50287555 CHEMBL4174695

SMILES Cc1noc(CNC(=O)c2ccc(C)c(c2)S(=O)(=O)Nc2ccc(Cl)cc2)n1

InChI Key InChIKey=DKFKIHZPQKGGTE-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50287555   

LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50: 62nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells at -75 mV holding potential by whole cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50: 85nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50: 85nMAssay Description:Inhibition of human ROMK2 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50: 777nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50: 794nMAssay Description:Inhibition of human ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50287555(CHEMBL4174695)
Affinity DataKi: >4.00E+4nMAssay Description:Displacement of fluorescent-labelled dofetilide from human ERG expressed in HEK293 cell membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2020
Entry Details Article
PubMed