BDBM50290811 5-Chloro-3H-benzooxazol-2-one::5-Chloro-benzooxazol-2-ol::5-chlorobenzo[d]oxazol-2(3H)-one::CHEMBL1371::CHLORZOXAZONE::Chlorozoxazone::Paraflex::Parafon forte dsc::Strifon forte dsc

SMILES Clc1ccc2oc(=O)[nH]c2c1

InChI Key InChIKey=TZFWDZFKRBELIQ-UHFFFAOYSA-N

Data  13 IC50

PDB links: 6 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50290811   

TargetUDP-glucuronosyltransferase 1A1(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUDP-glucuronosyltransferase 1A4(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUDP-glucuronosyltransferase 1-6(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUDP-glucuronosyltransferase 2B7(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUDP-glucuronosyltransferase 2B10(Human)
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >3.00E+5nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2J2(Human)
Tongji University

Curated by ChEMBL
LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNitric oxide synthase, inducible(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50:  1.41E+4nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePDB3D3D Structure (crystal)

TargetNitric oxide synthase, endothelial(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibitory activity against Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePDB3D3D Structure (crystal)

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNitric oxide synthase, brain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50290811(5-Chloro-3H-benzooxazol-2-one | 5-Chloro-benzooxaz...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article