BDBM50293150 CHEMBL468963::D3RKN_26::GSK screening, 38::N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine::TCMDC-138687

SMILES: CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1C(F)(F)F

InChI Key: InChIKey=ZOTNSCLLJKXGSD-UHFFFAOYSA-N

Data: 1 KI  7 IC50  9 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50293150   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PknB (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 4 (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 12 (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	435	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase pim-1 (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase mTOR (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase TBK1 (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	211	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PknB (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PknB (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK2 (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PknB (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM50293150 (N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...) Show SMILES Show InChI	GoogleScholar	UniChem		420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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