BDBM50293150 CHEMBL468963::D3RKN_26::GSK screening, 38::N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine::TCMDC-138687
SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1C(F)(F)F
InChI Key InChIKey=ZOTNSCLLJKXGSD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50293150
Affinity DataKi: 420nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant PknB (1 to 331 residues) expressed in Escherichia coli BL21-Rosetta cells using GarA and ATP as ...More data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:Binding affinity to human partial length Pim1 (A15 to K313 residues ) expressed in bacterial expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of GSK3beta by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human CDK2 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis recombinant PknB (1 to 331 residues) expressed in Escherichia coli BL21-Rosetta cells using GarA and ATP as ...More data for this Ligand-Target Pair
Affinity DataKd: 27nMAssay Description:Binding affinity to Mycobacterium tuberculosis recombinant N-terminal His-tagged PknB (1 to 331 residues) expressed in Escherichia coli DH5alpha cell...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human Cdk2/Cyclin A using Myelin basic protein as substrate by ATP competitive assayMore data for this Ligand-Target Pair
Affinity DataKd: 26nMAssay Description:Binding affinity to Mycobacterium tuberculosis partial length PknB (M1 to G279 residues) expressed in mammalian expression system by KdELECT kinase a...More data for this Ligand-Target Pair
Affinity DataKd: 4.5nMAssay Description:Binding affinity to human full length CDK4 (M1 to E303 residues) expressed in mammalian expression system/CyclinD3 by KdELECT kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 5.30nMAssay Description:Binding affinity to human full length GSK-3 beta (M1 to T433 residues) expressed in mammalian expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Binding affinity to human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by KdELECT kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 211nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK4 by radioactive glutathione plate-binding assayMore data for this Ligand-Target Pair