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BDBM50298441 5-(5-((S)-2-amino-3-(1H-indol-3-yl)propoxy)pyridin-3-yl)-3-(1H-imidazol-2-yl)indolin-2-one::CHEMBL579053

SMILES: N[C@H](COc1cncc(c1)-c1ccc2NC(=O)C(c3ncc[nH]3)c2c1)Cc1c[nH]c2ccccc12

InChI Key: InChIKey=IPSDVNHSWVWWKS-UBDBMELISA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50298441   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50298441
PNG
(5-(5-((S)-2-amino-3-(1H-indol-3-yl)propoxy)pyridin...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc2NC(=O)C(c3ncc[nH]3)c2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C27H24N6O2/c28-19(9-18-13-32-23-4-2-1-3-21(18)23)15-35-20-10-17(12-29-14-20)16-5-6-24-22(11-16)25(27(34)33-24)26-30-7-8-31-26/h1-8,10-14,19,25,32H,9,15,28H2,(H,30,31)(H,33,34)/t19-,25?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair