BDBM50298802 (+/-)-5-(3-(4'-tert-butyl-5-methoxybiphenyl-3-yl)but-1-ynyl)-6-methylpyrimidine-2,4-diamine::Biphenyl antifolate, 24::CHEMBL578424

SMILES COc1cc(cc(c1)-c1ccc(cc1)C(C)(C)C)C(C)C#Cc1c(C)nc(N)nc1N

InChI Key InChIKey=AOJOORYEHDDWCH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50298802   

TargetDihydrofolate reductase(Candida Glabrata)
University of Connecticut

LigandPNGBDBM50298802((+/-)-5-(3-(4'-tert-butyl-5-methoxybiphenyl-3-yl)b...)
Affinity DataIC50:  10nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298802((+/-)-5-(3-(4'-tert-butyl-5-methoxybiphenyl-3-yl)b...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298802((+/-)-5-(3-(4'-tert-butyl-5-methoxybiphenyl-3-yl)b...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298802((+/-)-5-(3-(4'-tert-butyl-5-methoxybiphenyl-3-yl)b...)
Affinity DataIC50:  210nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed